Signal Transduction Reagents and Kits
Enzo Life Sciences Calpeptin (10mg). CAS: 117591-20-5
Membrane permeable inhibitor of calpain I and II, cathepsin L and cathepsin K (IC50=0.11 nM). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin (ALX-450-006) or thrombin. Inhibits LPS induced iNOS transcription and NF-κB activation, possibly via proteasome inhibition. Alternative name: Z-Leu-norleucinal, N-Benzyloxycarbonyl-L-leucyl-norleucinal. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml or dimethyl formamide (5mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences D609 (5 mg). CAS: 83373-60-8
Selective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC). Has been used to study the coupling of phosphatidylcholine-specific phospholipase C with sphingomyelinase. Shows antitumor and antiviral activity. Inhibits basement membrane collagen synthesis, which is the last step in the development of a new blood vessel. Inhibits induction of nitric oxide synthases (NOS). Induces apoptosis. It indirectly inhibits phorbol ester stimulated PLD activity. Alternative name: Tricyclodecan-9-yl xanthogenate . K. Purity: ≥98% (TLC). Solubility: Soluble in water (25mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences BML-210 (1mg). CAS: 537034-17-6
HDAC inhibitor developed at Enzo Life Sciences. Inhibits HDAC activity in HeLa nuclear extracts (IC50=5-10µM). Purity: ≥98% (TLC). Solubility: Soluble in DMSO (25mg/ml) or 100% ethanol (10mg/ml, warm). Long Term Storage: -20°C.